Educational & Professional Experience

A.B. Biochemistry, Dartmouth College,1993.

Ph.D. Organic Chemistry, Montana State University, 2003.

Research Assistant, Glaxo-Wellcome, 1994-1996.

Senior Scientist, Nuada Pharmaceuticals, 2003-2005.

Research Scientist, Serenex, Inc., 2005.

Senior Research Scientist, Icagen, Inc., 2005-2009.

Senior Research Investigator, Icagen, Inc. 2009-2010.

Recent Publications

Swain, N.A., et al. Discovery of Clinical Candidate 4-[2-(5-Amino-1Hpyrazol-4-yl)-4-chlorophenoxy]-5-chloro-2-fluoro-N-1,3-thiazol-4-ylbenzenesulfonamide (PF-05089771): Design and Optimization of Diaryl Ether Aryl Sulfonamides as Selective Inhibitors of NaV1.7. J. Med. Chem., 2017, 60, 7029-7042. DOI:10.1021/acs.jmedchem.7b00598

Pryde, D.C., et al. The discovery of a potent NaV1.3 inhibitor with good oral pharmacokinetics.  Med. Chem. Commun., 2017, 8, 1255-1267. DOI:10.1039/C7MD00131B

Markworth, C.J.; Marron, B.E.; Rawson, D.J.; Storer, R.I.; Swain, N.A.; West, C.W.; Zhou, S.  Sulfonamide Compounds.  U.S. Patent 9,145,407, September 29, 2015.

Beaudoin, S.; Laufersweiler, M.C.; Markworth, C.J.; Marron, B.E.; Millan, D.S.; Rawson, D.J.; Reister, S.M.; Sasaki, K.; Storer, R.I.; Stupple, P.A.; Swain, N.A.; West, C.W.; Zhou, S. Sulfonamide Derivatives.  U.S. Patent 8,907,101, December 9, 2014.

Marron, B.E.; Fritch, P.C.; Markworth, C.J.; Maynard, A.T.; Swain, N.A.  Inhibitors of Ion Channels.  U.S. Patent 8,741,934, June 3, 2014.

Beaudoin, S.; Laufersweiler, M.C.; Markworth, C.J.; Marron, B.E.; Millan, D.S.; Rawson, D.J.; Reister, S.M.; Sasaki, K.; Storer, R.I.; Stupple, P.A.; Swain, N.A.; West, C.W.; Zhou, S. Sulfonamide Derivatives.  U.S. Patent 8,541,588, September 24, 2013.

Marron, B.E.; Fritch, P.C.; Markworth, C.J.; Maynard, A.T.; Swain, N.A.  Heterocyclic Sulfonamides as Inhibitors of Ion Channels.  U.S. Patent 8,357,711 January 22, 2013.

Huang, K.H., et al. Discovery of novel aminoquinazolin-7-yl-6,7-dihydro-indol-4-ones as potent, selective inhibitors of heat shock protein 90.  Bioorg. Med. Chem. Lett. 2012, 22, 2550-2554. DOI:10.1016/j.bmcl.2012.01.137