Independent Career (corresponding author*)

O'Neil, G. W.*, Keller, A.; Balila, J.; Golden, S.; Sipila, N.; Stone, B.; Nelson, R. K.; Reddy, C. M. "Monitoring Changes to Alkenone Biosynthesis in Commercial Tisochrysis lutea MicroalgaeACS Omega 2024ASAP.

Graphical Abstract_ONeilKeller

Clover, A. W.; Jones, A. P.; Berger, Robert F.; Kaminsky, W.; O'Neil, G. W.* "Regioselective Fluorohydrin Synthesis from Allylsilanes and Evidence for a Silicon-Fluorine Gauche EffectJ. Org. Chem. 2024, 89, 4309-4318.


Schwans, C. L.; Clark, T. D.; O'Neil, G. W.* "Hydroxyl-Directed Regio- and Diastereoselective Allylic Sulfone Reductions with [Sm(H2O)n]I2J. Org. Chem. 202489, 692-700.


Fomina, I. A.; Myers, C. R.; Soumis, C. L. M.; Scheuermann, M. L.; McCarty, J.; Clark, T. B.; O'Neil, G. W.* "Regiodivergent Medium-Ring Oxasilacycle Synthesis from DiallylsilanesHeterocycles 2022104, DOI: 10.3987/COM-22-14735.


O'Neil, G. W.* "Siletanes: Synthesis, Structure, and Reagents in Organic Synthesis. A ReviewOrg. Prep. Proced. Int. 2022, DOI: 10.1080/00304948.2021.2007018.

Myers, C. R.; Spaltenstein, P.; Baker, L. K.; Schwans, C. L.; Clark, T. B.; O'Neil, G. W.* "Sequential iodine-mediated diallylsilane rearrangement/asymmetric dihydroxylation: synthesis and reactions of enantioenriched oxasilacyclesTetrahedron Lett. 202182, 153392.

Gosselin, K. M.; Nelson, R. K.; Spivak, A. C.; Sylva, S. P.; Van Mooy, B. A. S.; Aeppli, C.; Sharpless, C. M.; O'Neil, G. W.; Arrington, E. C.; Reddy, C. M.; Valentine, D. L.* "Production of Two Highly Abundant 2‑Methyl-Branched Fatty Acids by Blooms of the Globally Significant Marine Cyanobacteria Trichodesmium erythraeumACS Omega 20216, 22803-22810.

O'Neil, G. W.*; Gale, A. C.; Nelson, R. K.; Dhaliwal, H. K.; Reddy, C. M. "Unusual Shorter-Chain C35 and C36 Alkenones from Commercially Grown Isochrysis sp. Microalgae" J. Am. Oil Chem. Soc.

Leitch, M. A.; O'Neil, G. W.* "Substrate-dependent stereospecificity in samarium-mediated allylic benzoate reductionsTetrahedron 202076, 131707. (Featured in Org. Chem. Highlights: Reduction)

Meyer, G. F.; Nistler, M. A.; Samoshin, A. V.; McManus, B. D.; Thane, T. A.; Ferber, C. J.; O'Neil, G. W.; Clark, T. B.* "β-​Silyloxy allylboronate esters through an aldehyde borylation​/homologation sequenceTetrahedron Lett. 202061, 152082.

Huynh, A.; Maktabi, B.; Reddy, C. M.; O'Neil, G. W.; Chandler, M.; Baki, G.* "Evaluation of alkenones, a renewably sourced, plant-​derived wax as a structuring agent for lipsticksInt. J. Cosmetic Sci. 202042, 146-155.

Stockdale, Trevor F.; Leitch, Michael A.; O'Neil, Gregory W.* "Chelation and Stereodirecting Group Effects on Regio- and Diastereoselective Samarium(II)​-​Water Allylic Benzoate ReductionsSynthesis 202052, 1544-1560. (highlighted in Synform)

McIntosh, K.; Sarver, J.; Mell, K.; Terrero, D. J.; Ashby, Jr., C. R.; Reddy, C. M.; O’ Neil, G. W.; Ramapuram, J. B.; Tiwari, A. K.​​​​​* "Oral and dermal toxicity of alkenones extracted from Isochrysis speciesFront. Biosci. 202025, 817-837.

Vincent, C. A.; Long, E. T.; Jones, H. C.; Young, J. C.; Spiegel, P. C.; O'Neil, G. W.* "Suzuki coupling-based synthesis of VATPase inhibitor archazolid natural product derived fragmentsRSC Adv. 20199, 32210-32218.

Huynh, A.; Abou-Dahech, M. S.; Reddy, C. M.; O'Neil, G. W.; Chandler, M.; Baki, G. "Alkenones, a Renewably Sourced, Biobased Wax as an SPF Booster for Organic SunscreensCosmetics 20196, 11.

Spaltenstein, P.; Cummins, E. J.; Yokuda, K-M.; Kowalczyk, T.; Clark, T. B.; O'Neil, G. W.* "Chemoselective Carbonyl Allylations with AlkoxyallylsiletanesJ. Org. Chem. 201984, 4421–4428.

O'Neil, G. W.*; Yen, T-Q.; Leitch, M. A.; Wilson, G. R.; Brown, E. A.; Rider, D. A.; Reddy, C. M. "Alkenones as renewable phase change materialsRenew. Energ. 2019134, 89-94.

McIntosh, K.; Smith, A.; Young, L. K.; Leitch, M. A.; Tiwari, A. K.; Reddy, C. M.; O'Neil, G. W.; Liberatore, M. W.; Chandler, M.; Baki, G. "Alkenones as a Promising Green Alternative for Waxes in Cosmetics and Personal Care ProductsCosmetics 2018, 5, 34.

Aeppli, C.*; Swarthout, R. F.; O'Neil, G. W.; Datz, S. D.; Nabi, D.; Ward, C. P.; Nelson, R. K.; Sharpless, C. M.; Reddy, C. M. "How persistent and bioavailable are oxygenated Deepwater Horizon oil transformation products?Environ. Sci. Technol. 201852, 7250.7258.

O'Neil, G. W.; Knothe, G. Reddy, C. M. "Jet Biofuels from Algae" in Biomass, Biofuels, Biochemicals: Biofuels from Algae 2nd Edition (Ed. A Pandey, DJ Lee, J-S Chang, Y Chisti, CR Soccol). Elsevier, 2018.

Stockdale, T. F.; O'Neil, G. W.* "Regio- and Diastereoselective Samarium-Mediated Allylic Benzoate ReductionsSynlett 201728, 2267-2271.

O'Neil, G. W.*, Cummins, E. J. "Iodine-mediated rearrangements of diallylsilanesTetrahedron Lett. 2017, 58, 3406-3409.

2O'Neil, G. W.*, Williams, J. R.; Craig, A. M., Nelson, R. K.; Gosselin, K. M.; Reddy, C. M. "Accessing Monomers, Surfactants, and the Queen Bee Substance by Acrylate Cross-Metathesis of Long-Chain AlkenonesJ. Am. Oil. Chem. Soc. 201794, 831-840.

O'Neil, G.W.*, Craig, A. M., Williams, J. R.; Young, J. C.; Spiegel, P. C. "Synthesis of the C1-C23 Fragment of the Archazolids and Evidence for V-ATPase but not COX Inhibitory ActivitySynlett 201728, 1101-1105. (highlighted in Synform)

O’Neil, G. W.*; Williams, J. R.; Wilson-Peltier, J.; Knothe, G.; Reddy, C. M. “Experimental Protocol for Biodiesel Production with Isolation of Alkenones as Coproducts from Commercial Isochrysis Algal BiomassJ. Vis. Exp. 2016, 112, doi:10.3791/54189.

Wright, A. M.; O’Neil, G. W.* “Total synthesis of honokiol by selective samarium-mediated allylic benzoate reductionTetrahedron Lett. 2016, 57, 3441-3443.

O’Neil, G. W.*; Knothe, G.; Williams, J. R.; Burlow, N. P.; Reddy, C. M. “Decolorization improves the fuel properties of algal biodiesel from Isochrysis sp.Fuel, 2016, 179, 229-234.

O’Neil, G. W.; Reddy, C. R. “A Faster Way to Better Reactions: 'One-pot' approach could speed syntheses of new products” Oceanus Magazine, Woods Hole Oceanographic Institution, Woods Hole, MA 2016.

O’Neil, G. W.*; Nelson, R. K.; Wright, A. M.; Reddy, C. M. “A One-​Pot​/Single-​Analysis Approach to Substrate Scope Investigations Using Comprehensive Two-​Dimensional Gas Chromatography (GC×GC)J. Org. Chem. 2016, 81, 3533-3541.

Phan, I. T.; Gilbert, G. J.; O’Neil, G. W.* “Ring-​Closing Metathesis Reactions of Acyloxysulfones: Synthesis of γ-​Alkylidene ButenolidesSynlett, 2015, 26, 1867-1871.

Swick, S. M.; Schaefer, S. L.; O’Neil, G. W.* “Synthesis of the C1-C17 fragment of the archazolids by complex cis-homodimer cross metathesisTetrahedron Lett. 2015, 56, 4039-4042.

O’Leary, D. J.; O’Neil, G. W. “Cross Metathesis” in Handbook of Metathesis, 2nd Edition, Volume 2: Applications in Organic Synthesis (Ed. R. H. Grubbs, D. J. O’Leary) Wiley-VCH: Weinheim, Germany 2015.

O’Neil, G. W.; Reddy, C. R. “Jet Fuel from Algae?” Oceanus Magazine, Woods Hole Oceanographic Institution, Woods Hole, MA 2015.

O’Neil, G. W.*; Culler, A. R.; Williams, J. R.; Burlow, N. P.; Gilbert, G. J.; Carmichael, C. A.; Nelson, R. K.; Swarthout, R. F.; Reddy, C. M. “Production of Jet Fuel Range Hydrocarbons as a Coproduct of Algal Biodiesel by Butenolysis of Long-Chain AlkenonesEnergy Fuels 2015, 29, 922-930.

King, B. R.; Swick, S. M.; Schaefer, S. L.; Welch, J. R.; Hunter, E. F.; O’Neil, G. W.* “Exploring a Ring-Closing Metathesis Approach to the Archazolid Macrocycle” Synthesis 2014, 46, 2927-2936.

O’Neil, G. W.*; Knothe, G.; Williams, J. R.; Burlow, N. P.; Culler, A. R.; Corliss, J. M.; Carmichael, C. A.; Reddy, C. M. “Synthesis and Analysis of an Alkenone-Free Biodiesel from Isochrysis sp.Energy Fuels, 2014, 28, 2677-2683.

Schaefer, S. L.; Roberts, C. L.; Volz, E. O.; Grasso, M. R.; O’Neil, G. W.* “Selective formation of non-conjugated olefins by samarium(II)-mediated elimination/isomerization of allylic benzoatesTetrahedron Lett. 2013, 54, 6125-6128.

Medina, C. R.; Carter, K. P.; Miller, M. M.; Clark, T. B.; O’Neil, G. W.* “Stereocontrolled Synthesis of 1,3-Diols from Enones: Cooperative Lewis-Base Mediated Intramolecular HydrosilylationsJ. Org. Chem. 2013, 78, 9093-9101.

O’Neil, G. W.*; Drake, N. D.; Storvick, J. M. “Addition/elimination reactions of ethylsulfonyl pyridines: stereoselective synthesis of vinylpyridine allylic alcoholsTetrahedron Lett. 2013 54, 715-717.

O’Neil, G. W.*; Carmichael, C. A.; Goepfert, T. J.; Fulton, J. M.; Knothe, G.; Lau, C. P-L. Lindell, S. R.; Mohammady, N. G-E.; Van Mooy, B. A. S.; Reddy, C. M. “Beyond Fatty Acid Methyl Esters: Expanding the Renewable Carbon Profile with Alkenones from Isochrysis sp.Energy Fuels, 2012, 26, 2434–2441.                       

Tran, A. B.; Melly, G.; Doucette, R.; Ashcraft, B.; Sebren, L.; Young, J.; O’Neil, G. W.* “Synthesis and activity of the archazolid western hemisphereOrg. Biomol. Chem. 2011, 9, 7671.

Storvick, J. K.; Ankoudinova, E.; King, B. R.; Van Epps, H.; O’Neil, G. W.* “Total synthesis of haminol A: An analysis of vinylpyridine metathesis reactivityTetrahedron Lett. 2011, 52, 5858.

Volz, E. O.; O’Neil, G. W.* “Chemoselective Samarium-Mediated Benzoyloxysulfone EliminationsJ. Org. Chem. 2011, 76, 8428.

Carter, K. P., Moser, D. J.; Storvick, J. M.; O’Neil, G. W.* “A masked-alkene metathesis-based synthesis of isopulo’uponeTetrahedron Lett. 2011, 52, 4494.

O’Neil, G. W.*; Miller, M. M.; Carter, K. P. “Direct Conversion of β-Hydroxyketones to Cyclic DisiloxanesOrg. Lett. 2010, 12, 5350.

O’Neil, G. W.*; Black, M. J. “A Synthesis of the C3-C15 Fragment of the ArchazolidsSynlett, 2010, 107.

O’Neil, G. W.*; Moser, D. J.; Volz, E. O. “Metathesis Reactions of β-Acyloxysulfones: Synthesis of 1,6- and 1,7-DienesTetrahedron Lett. 2009, 50, 7355.

Post-doctoral Studies

O’Neil, G. W.; Ceccon, J.; Benson, S.; Collin, M-P.; Fasching, B.; Fürstner, A.* “Total Synthesis of Spirastrellolide F Methyl Ester - Part 1: Strategic Considerations and Revised Approach to the Southern Hemisphere,” Angew. Chemie. I. E. 2009, 48, 9940.

Benson, S.; Collin, M-P.; O’Neil, G. W.; Ceccon, J.; Fasching, B.; Fenster, M. D. B.; Godbout, C.; Radkowski, K.; Goddard, R.; Fürstner, A.* “Total Synthesis of Spirastrellolide F Methyl Ester - Part 2: Macrocyclization and Completion of the Synthesis.” Angew. Chemie. I. E. 2009, 48, 9946.

O’Neil, G. W.; Fürstner, A.* “B-Alkyl Suzuki couplings for the stereoselective synthesis of substituted pyrans.” Chem. Commun. 2008, 4294.

Fürstner, A.*; Fasching, B.; O’Neil, G. W.; Fenster, M. D. B., Godbout, C.; Ceccon, J. “Toward the total synthesis of spirastrellolide A. Part 3: Intelligence gathering and preparation of a ring-expanded analogue.”  Chem. Commun. 2007, 3045.

Doctoral Studies

O'Neil, G. W.*; Phillips, A. J. "Synthesis of elaiolide and halichoblelide aglyconeTetrahedron Lett. 201960, 1413-1415.

O’Neil, G. W.; Phillips, A. J.* “Total Synthesis of (-)-Dictyostatin.” J. Am. Chem. Soc. 2006, 128, 5340.

O’Neil, G. W.; Phillips, A. J.* “Titanium(II)-mediated cyclization of (silyloxy)enynes: a synthesis of the C9 – C19 subunit of dictyostatin-1.” Tetrahedron Lett. 2004, 45, 4253.

Undergraduate Research

Reddy, C. M.*; Xu, L.; O’Neil, G. W.; Nelson, R. K.; Eglinton, T. I.; Faulkner, D. J.; Norstrom, R.; Ross, P. S.; Tittlemeier, S. A. “Radiocarbon evidence for a naturally-produced bio-accumulating halogenated organic compound.” Env. Sci. Technol. 2004, 38, 1992.